Posts

Gaia Hypothesis-Can there be a feedback without purpose?

[07/06, 4:57 pm] Dr Rakesh Biswas: https://www.quora.com/Why-cant-we-dig-deeper-than-12-2-km-into-the-Earth [08/06, 7:57 am] Dr Rakesh Biswas: I'm head over heels into the gaia hypothesis.  One individual cell inside the human universe is the Earth and we don't know which one. Can you guess?  Also what's the temperature difference between the surface and core of the cell? How do we even measure temperature? [08/06, 10:18 am] Dr.Dinesh Datta: We can measure temperature difference between surface and core of cell using thermocouples [08/06, 10:24 am] Dr.Dinesh Datta: Or microcalorimetry [08/06, 11:03 am] Dr Rakesh Biswas: Any data anywhere? [08/06, 12:08 pm] Dr.Dinesh Datta: Cellular metabolic heat (ΔPM) is produced from intracellular reactions, carrying information about particular processes thus indicating the status of organisms. ΔPM originating from a single cell is at pW level, making its determination based on the calorimetry technique challenging. Microcalorimetry, evo

2023 May to 2024 May in glimpse

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May 4th 2023-25th Birthday. May 5th.Invited to AIIMS Rishikesh as a panelist for G20 Y20 summit for discussion on 'Digital Health and Future of Healthcare' May 6th to May ending-Exploring Himalayas and conquering mountains.(Pics to be uploaded). June to September ending-Worked on an independent and interdisciplinary project on 'Value Based Medicine and AI in Healthcare'.It got published in Springer Nature and presented in IIIT Delhi in International conference on 'Big Data and Artificial Intelligence',Dec 7th to 9th. https://link.springer.com/chapter/10.1007/978-3-031-49601-1_2 Meanwhile,worked along with SATHI (sathi.org) for a BIS ICONS standards project along with a team from Switzerland. And some cherry on cake with this grateful recognition and award from CUBE(Collaboratively Understanding Biology Education)-an initiative by Homi Bhabha Centre for Science Education-Tata Institute of Fundamental Research. https://www3.hbcse.tifr.res.in/research-d

Appraising efficacy of Semaglutide in Metabolic Syndrome

[04/02, 8:59 am] Sumit CBBLE: I understand that you're extremely well regarded for metabolic syndrome and its implications. I had a question for you: Could semaglutide help manage or possibly treat metabolic syndrome? @⁨Dr Rakesh Biswas⁩ [04/02, 9:01 am] Sumit CBBLE: Open to discussion and inputs from everyone regarding implications of semaglutide. [04/02, 9:18 am] Dr.Dinesh Datta: No evidence to support its use in Metabolic syndrome. It's a weight lowering agent. Population: Patients aged 45 years or older with preexisting cardiovascular disease and a body-mass index (BMI) of 27 or greater, without diabetes. Intervention: Weekly subcutaneous semaglutide at a dose of 2.4 mg. Comparision: Placebo. Outcome- Reduction in the incidence of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke over a mean follow-up period of 39.8 months.  This multicenter, double-blind, randomized, placebo-controlled, event-driven superiority trial included 17,604 patie

Critical appraisal on REN(Remote Electrical Neuromodulation) by Dr Reddy's-Digital Therapeutics

[06/05, 8:42 am] Dr Rakesh Biswas: We were recently discussing one of our migraine patient's journey record and clinical events monitoring and we became aware of this tech marketed by Dr Reddy's : Question is: does Dr Reddy's hold a patent on Remote Electrical Neuromodulation (REN)? It does supplement the tech with other biofeedback as well as patient event headache journey monitoring tech although it's key feature is REN.  Question 2: What's the scientific evidence of REN in terms of efficacy (preferably in a PICO format)?  News clip that stimulated the above two answer finding journeys: https://timesofindia.indiatimes.com/gadgets-news/dr-reddys-nerivio-device-review-smart-pain-relief/articleshow/107822357.cms [06/05, 1:00 pm] Hemanth AI Pune: There are multiple research paper in this showcasing thier finding [06/05, 1:04 pm] Hemanth AI Pune: Theranica Enters Into Agreement With Dr. Reddy's for Commercializing Nerivio® in India [06/05, 1:06 pm] Hemanth AI Pune:

Patient centred biochemistry of COPD patients, their renal comorbidities and outcomes

70M with multiple myeloma remission looking for alternative/unconventional therapy/dietary ketosis.

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This is an online E log book to discuss our patient's de-identified health data shared after taking his/her/guardian's signed informed consent. Here we discuss our individual patient's problems through series of inputs from global online community of experts with an aim to solve those patient's clinical problems with collective current best evidence based inputs. Patient: 'Here's a quick summary of my medical history that may be relevant to my condition: 'I'm a 70 year old mathematician/professor of computer science. I have worked on a number of medical projects with clinicians but have had no clinical training but I hope some understanding of some clinical issues. In 2005 I was diagnosed as a T2 diabetic which I was successfully controlling with a ketogenic diet ( eg my BGL in the morning before breakfast was 4 - 5 mmol/L before I had COVID in June 2022 after which it was consistently 2 mmol/L greater) before I started taking dexamethasone which has req

Conversational appraisal of 'liverdoc's article'

[20/02, 8:33 pm] Dr.Dinesh Datta:(Forwarded from other group) Any ayurvedic practitioner on the group, can you pls throw some light on use of heavy metals in medicines? Is it ok to take under medical supervision? I read somewhere about Ras-shastra and Nagarjuna. [20/02, 8:33 pm] Dr.Dinesh Datta: But then there are reports of heavy metal poisoning too on Pubmed due to ayurvedic preparations, what is the catch?? [20/02, 8:37 pm] Dr Rakesh Biswas: The catch is in dose optimization!  Holds true for all drugs be it any system of medicine [20/02, 8:58 pm] +91 93714 56707: My thoughts: the conventional method of preparing ayur drugs i.e. the ras aushadhis which have metallic content is pretty elaborate...eg soak them in lemon juice for x number of days, or triturate together for x hours...these are primarily for those containing the mercury and sulphur combinations....however in current usage Pharma companies may not be diligently following those methods of preparation...and I am not sure of